Glysolin N Mechanism of Action

Pharmacology: Pharmacodynamics: Mechanism of Action: Recombinant Isophane Insulin-NPH (Glysolin N) is human recombinant insulin, which is synthesized in a special non-disease producing laboratory strain of the yeast Hansenula polymorpha. This special host cell line has been genetically altered by the addition of the gene for the human insulin production.
It is an amorphous and crystalline suspension of human insulin with zinc in providing intermediate-acting insulin with a lower onset and a longer duration of activity than that of regular insulin. The onset of action of Isophane Insulin Human Suspension-NPH (Glysolin N) is dependent on dose, site of injection, blood supply, temperature and physical activity. The onset of action is 1-2 hours, peak effect is seen at 6-12 hours and the duration of effect is about 18-24 hours. The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. It is a sterile solution and is for subcutaneous injection only. It should not be used intravenously or intramuscularly.
Pharmacokinetics: Insulin has a half-life of a few minutes in the blood stream. Consequently, the time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. As with insulin preparations, the intensity and duration of action of Isophane Insulin Human Suspension-NPH (Glysolin N) is dependent on the dose, site of injection, blood supply, temperature, and physical activity.
An average action profile after subcutaneous injection indicates: Onset within 1-2 hours.
Peak levels attained between 6-12 hours.
Duration of action approximately 18-24 hours.